The £23m investment will come via The Engineering and Physical Sciences Research Council and will support the centres over the next five years. The centres will be hosted by the Universities of York, Bath, and Nottingham, Swansea University, UCL and Newcastle University.
"This latest investment demonstrates our commitment to maximising the digital revolution for the UK," Universities and Science Minister Jo Johnson said. "These Centres will lead the way in developing innovative digital products which enhance our daily lives - from personalised digital health services to the use of interactive media in education."
The centres will focus on a wide variety of areas and potential applications, such as improving motion capture technology, refining the ethical use of personal data, designing technology for interactive media, health, social care and cybersecurity and to help rebalance the national economy.
They will build on the UK's existing academic strengths, grow and develop the pool of interdisciplinary trained researchers and work together to help position the country as a world leader in Digital Economy research.